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KMID : 1145520170030020103
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 2 p.103 ~ p.112
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Radiolabeling of nanoparticle for enhanced molecular imaging
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Kim Ho-Young
Lee Yun-Sang
Jeong Jae-Min
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Abstract
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The combination of nanoparticle with radioisotope could give the in vivo information with high sensitivity and specificity. However, radioisotope labeling of nanoparticle is very difficult and radioisotopes have different physicochemical properties, so the radioisotope selection of nanoparticle should be carefully considered. 18F was first option to be considered for labeling of nanoparticle. For the labeling of 18F with nanoparticle, Prosthetic group is widely used. Iodine, another radioactive halogen, is often used. Since radioiodine isotopes are various, they can be used for different imaging technique or therapy in the same labeling procedures. 99mTc can easily be obtained as pertechnatate (99mTcO4-) by commercial generator. Ionic 68Ga (III) in dilute HCl solution is also obtained by generator system, but 68Ga can be substituted for 67Ga because of the short half-life (67.8 min). 64Cu emits not only positron but also ß- particle. Therefore 64Cu can be used for imaging and therapy at the same time. These radioactive metals can be labeled with nanoparticle using the bifunctional chelator. 89Zr has longer half-life (78.4 h) and is used for the longer imaging time. Unlike different metals, 89Zr should use the other chelate such as DFO, 3,4,3-(LI-1,2-HOPO) or DFOB.
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KEYWORD
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Nanoparticle, Radiohalogen, Radiometal, PET, SPECT
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